Solution Structure and Mechanism of the MutT Pyrophosphohydrolase
- Daniel L. Purich
Published Online: 22 NOV 2006
DOI: 10.1002/9780470123195.ch6
Copyright © 1999 by John Wiley & Sons, Inc.
Book Title
Advances in Enzymology and Related Areas of Molecular Biology: Mechanism of Enzyme Action, Part A, Volume 73
Additional Information
How to Cite
Mildvan, A.S., Weber, D.J. and Abeygunawardana, C. (2006) Solution Structure and Mechanism of the MutT Pyrophosphohydrolase, in Advances in Enzymology and Related Areas of Molecular Biology: Mechanism of Enzyme Action, Part A, Volume 73 (ed D. L. Purich), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123195.ch6
Editor Information
University of Florida College of Medicine, Gainesville, Florida
Publication History
- Published Online: 22 NOV 2006
- Published Print: 1 JAN 1999
ISBN Information
Print ISBN: 9780471246442
Online ISBN: 9780470123195
- Summary
- Chapter
- References
Keywords:
- MutT pyrophosphohydrolase;
- bond cleavage;
- free MutT enzyme;
- MutT reaction;
- quaternary MutT-M2+-AMPCPP-M2+ complex
Summary
This chapter contains sections titled:
Introduction
Site of Bond Cleavage by the MutT Enzyme
Catalytic Power of Pyrophosphoryl Transferring Enzymes
Role of Divalent Cations in Pyrophosphoryl Transferring Enzymes
Solution Structure of the Free MutT Enzyme
Solution Structure of the Quaternary MutT-M2+ —AMPCPP—M2+ Complex
The Active Site of the MutT Enzyme
Summary and Conclusions