The Molecular Evolution of Pyridoxal-5′-Phosphate-Dependent Enzymes

  1. Daniel L. Purich
  1. Perdeep K. Mehta,
  2. Philipp Christen

Published Online: 22 NOV 2006

DOI: 10.1002/9780470123201.ch4

Advances in Enzymology and Related Areas of Molecular Biology, Volume 74

Advances in Enzymology and Related Areas of Molecular Biology, Volume 74

How to Cite

Mehta, P. K. and Christen, P. (2006) The Molecular Evolution of Pyridoxal-5′-Phosphate-Dependent Enzymes, in Advances in Enzymology and Related Areas of Molecular Biology, Volume 74 (ed D. L. Purich), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470123201.ch4

Editor Information

  1. University of Florida College of Medicine, Gainesville, Florida

Author Information

  1. Biochemisches Institut der Universität Zürich, CH-8057 Zürich, Switzerland

Publication History

  1. Published Online: 22 NOV 2006
  2. Published Print: 1 JAN 2000

ISBN Information

Print ISBN: 9780471349211

Online ISBN: 9780470123201

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Keywords:

  • pyridoxal-5′-phosphate-dependent catalytic antibodies;
  • B6 enzymes;
  • amino acid substrates;
  • catalytic mechanisms;
  • experimental simulation

Summary

This chapter contains sections titled:

  • Introduction

  • Databases and Methodology

  • Emergence and Evolution of B6 Enzymes

  • Experimental Simulation of Steps of B6 Enzyme Evolution

  • Alternatives for and to Pyridoxal-5′-phosphate

  • Conclusions and Perspectives