1. Development of Vaccine Adjuvants: A Historical Perspective

  1. Manmohan Singh M. Pharm., Ph.D.
  1. Gary Ott and
  2. Gary Van Nest

Published Online: 2 NOV 2006

DOI: 10.1002/9780470134931.ch1

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems

How to Cite

Ott, G. and Van Nest, G. (2007) Development of Vaccine Adjuvants: A Historical Perspective, in Vaccine Adjuvants and Delivery Systems (ed M. Singh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470134931.ch1

Editor Information

  1. Novartis Vaccines, Emeryville, California, USA

Author Information

  1. Dynavax Technologies Corporation, Berkeley, California, USA

Publication History

  1. Published Online: 2 NOV 2006
  2. Published Print: 15 JUN 2007

ISBN Information

Print ISBN: 9780471739074

Online ISBN: 9780470134931

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Keywords:

  • vaccine adjuvant research and development;
  • specific immune activation or delivery–depot effect;
  • rational receptor-associated adjuvants

Summary

This chapter contains sections titled:

  • Introduction

  • Initial Development of Adjuvants for Toxoid Vaccines: 1920s–1940s

  • Broadened Use of Aluminum and Oil Adjuvants: 1940s–1970s

  • Rational Receptor-Driven Adjuvants that Activate the Innate Immune System: 1990s-Present

  • Conclusions

  • References