15. Polyphosphazenes as Vaccine Adjuvants

  1. Manmohan Singh M. Pharm., Ph.D.
  1. Alexander K. Andrianov

Published Online: 2 NOV 2006

DOI: 10.1002/9780470134931.ch15

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems

How to Cite

Andrianov, A. K. (2007) Polyphosphazenes as Vaccine Adjuvants, in Vaccine Adjuvants and Delivery Systems (ed M. Singh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470134931.ch15

Editor Information

  1. Novartis Vaccines, Emeryville, California, USA

Author Information

  1. Apogee Technology, Inc., Norwood, Massachusetts, USA

Publication History

  1. Published Online: 2 NOV 2006
  2. Published Print: 15 JUN 2007

ISBN Information

Print ISBN: 9780471739074

Online ISBN: 9780470134931



  • polyphosphazenes as vaccine adjuvants;
  • poly[di(carboxylatophenoxy)phosphazene] (PCPP);
  • microencapsulation systems and polyphosphazene adjuvants


This chapter contains sections titled:

  • Introduction

  • Synthesis of Polyphosphazene Adjuvants

  • Adjuvant Activity of PCPP: A Lead Compound

  • PCPP in Clinical Trials

  • Hydrolic Degradation of Polyphosphazene Polyacids

  • Formulation Aspects and Notes on the Mechanism of Action

  • New Polyphosphazene Immunoadjuvants and High-Throughput Methods for their Discovery

  • Microencapsulation Systems Based on Polyphosphazene Adjuvants

  • Conclusions

  • References