3. Mechanisms of Adjuvant Action

  1. Manmohan Singh M. Pharm., Ph.D.
  1. Nils Lycke

Published Online: 2 NOV 2006

DOI: 10.1002/9780470134931.ch3

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems

How to Cite

Lycke, N. (2007) Mechanisms of Adjuvant Action, in Vaccine Adjuvants and Delivery Systems (ed M. Singh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470134931.ch3

Editor Information

  1. Novartis Vaccines, Emeryville, California, USA

Author Information

  1. Department of Microbiology and Immunology, Institute of Biomedicine, University of Göteborg, Göteborg, Sweden

Publication History

  1. Published Online: 2 NOV 2006
  2. Published Print: 15 JUN 2007

ISBN Information

Print ISBN: 9780471739074

Online ISBN: 9780470134931



  • adjuvant action mechanisms;
  • combination adjuvants with CTA1-DD;
  • nontoxic CTA1-DD adjuvant


This chapter contains sections titled:

  • Introduction

  • Induction of Immunity

  • Overview of Adjuvant Mechanisms

  • Targeting as a Means to Exert Adjuvant Function

  • Adjuvant Function and Toxicity

  • Specific Mechanisms Via the Toll-Like Receptors

  • NOD Receptors

  • Particulate Antigen Delivery: Microparticles/Viruslike Particles/Liposomes and Immunostimulating Complexes

  • Combination Adjuvants

  • Mucosal Vaccine Adjuvants

  • Cholera Toxin: The Prototype Adjuvant

  • Searching for In Vivo Correlates of Adjuvant Action

  • Toxins are too Toxic for Clinical Use

  • Nontoxic CTA1-DD Adjuvant

  • Gene Expression Profiling

  • Combination Adjuvants with CTA1-DD

  • Concluding Remarks

  • Acknowledgments

  • References