5. MF59: A Safe and Potent Oil-in-Water Emulsion Adjuvant

  1. Manmohan Singh M. Pharm., Ph.D.
  1. Derek T. O'Hagan and
  2. Manmohan Singh M. Pharm., Ph.D.

Published Online: 2 NOV 2006

DOI: 10.1002/9780470134931.ch5

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems

How to Cite

O'Hagan, D. T. and Singh, M. (2006) MF59: A Safe and Potent Oil-in-Water Emulsion Adjuvant, in Vaccine Adjuvants and Delivery Systems (ed M. Singh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470134931.ch5

Editor Information

  1. Novartis Vaccines, Emeryville, California, USA

Author Information

  1. Novartis Vaccines, Emeryville, California, USA

Publication History

  1. Published Online: 2 NOV 2006
  2. Published Print: 15 JUN 2007

ISBN Information

Print ISBN: 9780471739074

Online ISBN: 9780470134931

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Keywords:

  • safe and potent oil-in-water emulsion adjuvant;
  • MF59 combination with immunopotentiators;
  • MF59 tolerability profile in pediatric populations

Summary

This chapter contains sections titled:

  • Emulsions as Adjuvants

  • Initial Development of MF59 Oil-in-Water Adjuvant

  • Mechanism of Action of MF59 Adjuvant

  • Composition of MF59

  • Manufacturing of MF59

  • Preclinical Experience with MF59

  • Clinical Experience with MF59 Adjuvant

  • Combination of MF59 with Immunopotentiators

  • Use of MF59 in Prime–Boost Settings

  • Future Perspectives on the Use of MF59

  • Acknowledgments

  • References