6. TLR4 Agonists as Vaccine Adjuvants

  1. Manmohan Singh M. Pharm., Ph.D.
  1. David A. Johnson and
  2. Jory R. Baldridge

Published Online: 2 NOV 2006

DOI: 10.1002/9780470134931.ch6

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems

How to Cite

Johnson, D. A. and Baldridge, J. R. (2007) TLR4 Agonists as Vaccine Adjuvants, in Vaccine Adjuvants and Delivery Systems (ed M. Singh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470134931.ch6

Editor Information

  1. Novartis Vaccines, Emeryville, California, USA

Author Information

  1. GlaxoSmithKline-Biologicals, Hamilton, Montana, USA

Publication History

  1. Published Online: 2 NOV 2006
  2. Published Print: 15 JUN 2007

ISBN Information

Print ISBN: 9780471739074

Online ISBN: 9780470134931



  • TLR4 agonists as vaccine adjuvants;
  • synergism between TLR4;
  • TLR4 agonists as vaccine adjuvants


This chapter contains sections titled:

  • Introduction

  • TLR4-Mediated Induction of Adaptive Immunity

  • Naturally Derived Lipid A Derivatives and Synthetic Lipid A Mimetics

  • Self-Adjuvanted Vaccines: TLR4 Agonist–Antigen Constructs

  • Synergism Between TLR4 and other TLR Agonists or Vaccine Adjuvants

  • Rapid-Acting Vaccines

  • TLR4-Active Vaccine Adjuvants: Concluding Remarks

  • References