5. NMR Structural Studies of Aminoglycoside: RNA Interaction

  1. Dev P. Arya
  1. R. Andrew Marshall1 and
  2. Joseph D. Puglisi2

Published Online: 3 JAN 2007

DOI: 10.1002/9780470149676.ch5

Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery

Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery

How to Cite

Marshall, R. A. and Puglisi, J. D. (2007) NMR Structural Studies of Aminoglycoside: RNA Interaction, in Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery (ed D. P. Arya), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470149676.ch5

Editor Information

  1. Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA

Author Information

  1. 1

    Department of Chemistry, Stanford University, Stanford, CA 94305, USA

  2. 2

    Department of Structural Biology, Stanford University, Stanford, CA 94305, USA

Publication History

  1. Published Online: 3 JAN 2007
  2. Published Print: 1 JUN 2007

ISBN Information

Print ISBN: 9780471743026

Online ISBN: 9780470149676

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Keywords:

  • NMR and aminoglycoside - RNA interaction;
  • oligonucleotide model of ribosomal A-site;
  • prokaryotic specificity of aminoglycosides

Summary

This chapter contains sections titled:

  • Introduction

  • An Oligonucleotide Model of the Ribosomal A-Site

  • Structural Aspects of Aminoglycoside Binding to A-Site Oligonucleotide

  • Structural Insights into Aminoglycoside Resistance

  • Structural Origins of Aminoglycoside-Induced Miscoding

  • Prokaryotic Specificity of Aminoglycosides

  • Comparison of Structures Solved by NMR and X-Ray Crystallography

  • Structures of Aminoglycosides with Other RNAs

  • NMR in the Design of Aminoglycoside Mimetics

  • Perspectives

  • References