Chapter 2. Nucleic Acid Delivery and Localizing Delivery with Magnetic Nanoparticles

  1. Dr. Vinod Labhasetwar Ph.D. staff scientist postdoctoral fellow faculty member associate professor professor2 and
  2. Dr. Diandra L. Leslie-Pelecky Ph.D. associate professor3
  1. Christian Plank,
  2. Ulrike Schillinger,
  3. Dialekti Vlaskou and
  4. Olga Mykhaylyk

Published Online: 3 JAN 2007

DOI: 10.1002/9780470152928.ch2

Biomedical Applications of Nanotechnology

Biomedical Applications of Nanotechnology

How to Cite

Plank, C., Schillinger, U., Vlaskou, D. and Mykhaylyk, O. (2007) Nucleic Acid Delivery and Localizing Delivery with Magnetic Nanoparticles, in Biomedical Applications of Nanotechnology (eds V. Labhasetwar and D. L. Leslie-Pelecky), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470152928.ch2

Editor Information

  1. 2

    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

  2. 3

    Department of Physics and Astronomy, Nebraska Center for Materials Nanoscience and Nanoscience, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

Author Information

  1. Institute of Experimental Oncology, Technische Universität München, Munich, Germany

Publication History

  1. Published Online: 3 JAN 2007
  2. Published Print: 30 JUL 2007

ISBN Information

Print ISBN: 9780471722427

Online ISBN: 9780470152928



  • magnetically targeted nucleic acid delivery;
  • vector localization by magnetic force (magnetofection);
  • drug localization and nucleic acid delivery


This chapter contains sections titled:

  • Introduction

  • Nucleic Acid Delivery—What for?

  • Nucleic Acid Delivery—How?

  • Why is Localization of Drug and Nucleic Acid Delivery Important?

  • Methods of Localization and of Local Control

  • Establishing Target Cell Contact

  • Vector Localization by Magnetic Force (Magnetofection)

  • Use of Ultrasound to Trigger Localized Delivery, Microbubbles, and Magnetic Microbubbles

  • Concluding Remarks

  • References