Chapter 10. Allogeneic Whole-Cell Vaccines

  1. Rimas Orentas PhD2,
  2. James W. Hodge PhD3 and
  3. Bryon D. Johnson PhD4
  1. John Copier PhD and
  2. Angus Dalgleish Bsc (Hons), MD, FRACPath, FRACP, FRCP, FMed-Sci

Published Online: 1 MAR 2007

DOI: 10.1002/9780470170113.ch10

Cancer Vaccines and Tumor Immunity

Cancer Vaccines and Tumor Immunity

How to Cite

Copier, J. and Dalgleish, A. (2008) Allogeneic Whole-Cell Vaccines, in Cancer Vaccines and Tumor Immunity (eds R. Orentas, J. W. Hodge and B. D. Johnson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470170113.ch10

Editor Information

  1. 2

    Departments of Pediatrics, Medicine, Microbiology and Molecular Genetics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA

  2. 3

    Department of Medical Biology, University of Tennessee Medical Center and Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

  3. 4

    Department of Pediatrics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin., Milwaukee, WI, USA

Author Information

  1. Oncology/Cellular and Molecular Medicine, St. George's University of London, London, UK

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: 22 JAN 2008

ISBN Information

Print ISBN: 9780470074749

Online ISBN: 9780470170113

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Keywords:

  • allogeneic whole-cell vaccines;
  • GM-CSF-secreting autologous vaccines;
  • allogeneic tumor cell lysates in prostate cancer

Summary

This chapter contains sections titled:

  • Introduction

  • How Whole-Cell Vaccines Elicit Effective T Cell Responses

  • Advantages of Whole-Cell Vaccines

  • Effectiveness of Allogeneic Whole-Cell Vaccination

  • Modification of Allogeneic Cell Vaccines with Costimulatory Molecules

  • Modification of Allogeneic Vaccines to Secrete Cytokines

  • Future Research

  • Conclusions

  • References