Chapter 12. T-Regulatory Cell Manipulation in Tumor Immunotherapy

  1. Rimas Orentas PhD7,
  2. James W. Hodge PhD8 and
  3. Bryon D. Johnson PhD9
  1. Jens Rüter MD1,
  2. Brian G. Barnett MD2,
  3. Ilona Kryczek PhD3,
  4. Michael J. Brumlik PhD1,
  5. Benjamin J. Daniel PhD1,
  6. George Coukos MD, PhD4,
  7. Weiping Zou MD, PhD3 and
  8. Tyler J. Curiel MD, MPH Director5,6

Published Online: 1 MAR 2007

DOI: 10.1002/9780470170113.ch12

Cancer Vaccines and Tumor Immunity

Cancer Vaccines and Tumor Immunity

How to Cite

Rüter, J., Barnett, B. G., Kryczek, I., Brumlik, M. J., Daniel, B. J., Coukos, G., Zou, W. and Curiel, T. J. (2008) T-Regulatory Cell Manipulation in Tumor Immunotherapy, in Cancer Vaccines and Tumor Immunity (eds R. Orentas, J. W. Hodge and B. D. Johnson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470170113.ch12

Editor Information

  1. 7

    Departments of Pediatrics, Medicine, Microbiology and Molecular Genetics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA

  2. 8

    Department of Medical Biology, University of Tennessee Medical Center and Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

  3. 9

    Department of Pediatrics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin., Milwaukee, WI, USA

Author Information

  1. 1

    The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

  2. 2

    Tulane Medical School, New Orleans, LA, USA

  3. 3

    The University of Michigan, Ann Arbor, MI, USA

  4. 4

    University of Pennsylvania, Philadelphia, PA, USA

  5. 5

    San Antonio Cancer Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

  6. 6

    Scientific Director, Cancer Therapy and Research Center, San Antonio, San Antonio, TX, USA

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: 22 JAN 2008

ISBN Information

Print ISBN: 9780470074749

Online ISBN: 9780470170113

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Keywords:

  • T-regulatory cell manipulation;
  • blocking Treg trafficking;
  • CD4+CD25+ T-regulatory cells (Tregs)

Summary

This chapter contains sections titled:

  • Introduction

  • T-Regulatory Cell Depletion

  • Functional Blockade of T-Regulatory Cells

  • Interactions between T-Regulatory and other Cells

  • Vascular Leukocytes

  • T-Regulatory Cells and Tumor Vaccines

  • Summary And Conclusions

  • References