Chapter 14. Vaccines in the Setting of Hematopoietic Stem Cell Transplantation

  1. Rimas Orentas PhD3,
  2. James W. Hodge PhD4 and
  3. Bryon D. Johnson PhD5
  1. Ronald Gress MD Chief1 and
  2. Claude Sportes MD2

Published Online: 1 MAR 2007

DOI: 10.1002/9780470170113.ch14

Cancer Vaccines and Tumor Immunity

Cancer Vaccines and Tumor Immunity

How to Cite

Gress, R. and Sportes, C. (2008) Vaccines in the Setting of Hematopoietic Stem Cell Transplantation, in Cancer Vaccines and Tumor Immunity (eds R. Orentas, J. W. Hodge and B. D. Johnson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470170113.ch14

Editor Information

  1. 3

    Departments of Pediatrics, Medicine, Microbiology and Molecular Genetics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA

  2. 4

    Department of Medical Biology, University of Tennessee Medical Center and Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

  3. 5

    Department of Pediatrics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin., Milwaukee, WI, USA

Author Information

  1. 1

    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

  2. 2

    Clinical Research Core, Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: 22 JAN 2008

ISBN Information

Print ISBN: 9780470074749

Online ISBN: 9780470170113

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Keywords:

  • antigen exposure postimmune depletion;
  • T cell regeneration optimization;
  • conventional chemoradiotherapies and immune interventions

Summary

This chapter contains sections titled:

  • Introduction

  • Transplantation, Tumor Mass, and Time

  • Transplantation and a Window of Survival: An Example

  • Alternatives to High-Dose Chemotherapy for Controlling Disease: T Cell Depletion Outside the Setting of High-Dose Chemotherapy

  • Antigen Exposure Postimmune Depletion: T Cell Repertoire Reconstitution

  • Optimizing T Cell Regeneration

  • Vaccine Strategies: Target Antigens and Tolerance

  • Conclusions

  • References