Chapter 16. Cancer Immunotherapy: Untapping the Potential of Costimulatory Molecules Beyond CTLA-4

  1. Rimas Orentas PhD3,
  2. James W. Hodge PhD4 and
  3. Bryon D. Johnson PhD5
  1. Mathew Augustine MD1 and
  2. Lieping Chen MD, PhD2

Published Online: 1 MAR 2007

DOI: 10.1002/9780470170113.ch16

Cancer Vaccines and Tumor Immunity

Cancer Vaccines and Tumor Immunity

How to Cite

Augustine, M. and Chen, L. (2008) Cancer Immunotherapy: Untapping the Potential of Costimulatory Molecules Beyond CTLA-4, in Cancer Vaccines and Tumor Immunity (eds R. Orentas, J. W. Hodge and B. D. Johnson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470170113.ch16

Editor Information

  1. 3

    Departments of Pediatrics, Medicine, Microbiology and Molecular Genetics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA

  2. 4

    Department of Medical Biology, University of Tennessee Medical Center and Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

  3. 5

    Department of Pediatrics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin., Milwaukee, WI, USA

Author Information

  1. 1

    Departments of Immunology and Surgery, The Johns Hopkins School of Medicine The Johns Hopkins Hospital, Baltimore, MD, USA

  2. 2

    Departments of Dermatology, Oncology, and Immunology, and The Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: 22 JAN 2008

ISBN Information

Print ISBN: 9780470074749

Online ISBN: 9780470170113

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Keywords:

  • monocyte-derived myeloid dendritic cells (MDCs);
  • CD137L pathway and immune response;
  • tumor-infiltrating lymphocytes

Summary

This chapter contains sections titled:

  • Introduction

  • PD-1/ B7-H1/ B7-DC Pathway

  • CD137 and CD137 Ligand

  • Conclusions

  • References