Chapter 4. Stimulation of Toll-Like Receptor 9 for Enhancing Vaccination

  1. Rimas Orentas PhD3,
  2. James W. Hodge PhD4,
  3. Bryon D. Johnson PhD5
  1. Daniel E. Speiser MD1,
  2. Arthur M. Krieg MD2

Published Online: 1 MAR 2007

DOI: 10.1002/9780470170113.ch4

Book Title

Cancer Vaccines and Tumor Immunity

Cancer Vaccines and Tumor Immunity

Additional Information

How to Cite

Speiser, D. E. and Krieg, A. M. (2007) Stimulation of Toll-Like Receptor 9 for Enhancing Vaccination, in Cancer Vaccines and Tumor Immunity (eds R. Orentas, J. W. Hodge and B. D. Johnson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470170113.ch4

Editor Information

  1. 3

    Departments of Pediatrics, Medicine, Microbiology and Molecular Genetics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI, USA

  2. 4

    Department of Medical Biology, University of Tennessee Medical Center and Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

  3. 5

    Department of Pediatrics, Medical College of Wisconsin and the Children's Research Institute, Children's Hospital of Wisconsin., Milwaukee, WI, USA

Author Information

  1. 1

    Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, University Hospital of Lausanne, Switzerland

  2. 2

    Department of Internal Medicine, The University of Iowa, Iowa City, IA, and Coley Pharmaceutical Group, Wellesley, MA, USA

Publication History

  1. Published Online: 1 MAR 2007
  2. Published Print: 22 JAN 2008

ISBN Information

Print ISBN: 9780470074749

Online ISBN: 9780470170113

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Keywords:

  • toll-like receptors (TLRs) and innate immune responses;
  • CpG ODN adjuvants and infectious disease vaccines;
  • TLR9 activation with CpG ODN

Summary

This chapter contains sections titled:

  • Introduction

  • The Role of TLR9 as Receptor for CpG ODN

  • Identification of Distinct Classes of Immune Stimulatory CpG ODN

  • CpG ODN Mechanisms Action in Stimulating Innate and Adaptive Immunity

  • CpG ODN as Adjuvants for Infectious Disease Vaccines

  • CpG ODN Synergy with other Adjuvants

  • Human Clinical Trials with CpG ODN to Adjuvant Infectious Disease Vaccines

  • Efficacy of CpG ODN as Vaccine Adjuvants in Mouse Tumor Models

  • Human Clinical Trials of CpG ODN Adjuvants for Cancer Vaccines

  • Safety of CpG ODN as Vaccine Adjuvant

  • Conclusions

  • References

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