12. Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function

  1. Kenneth E. Gonsalves3,
  2. Craig R. Halberstadt4,5,
  3. Cato T. Laurencin6,7 and
  4. Lakshmi S. Nair6
  1. Tanmay Lele1 and
  2. Donald E. Ingber2

Published Online: 11 APR 2007

DOI: 10.1002/9780470185834.ch12

Biomedical Nanostructures

Biomedical Nanostructures

How to Cite

Lele, T. and Ingber, D. E. (2007) Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function, in Biomedical Nanostructures (eds K. E. Gonsalves, C. R. Halberstadt, C. T. Laurencin and L. S. Nair), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470185834.ch12

Editor Information

  1. 3

    Polymer Nanotechnology Laboratory, Department of Chemistry and Center for Optoelectronics and Optical Communication, University of North Carolina, Charlotte, NC, USA

  2. 4

    Department of Surgery, Carolinas Medical Center, USA

  3. 5

    Tengion, Inc., Winston Salem, NC, USA

  4. 6

    Department of Orthopaedic Surgery, University of Virginia, VA, USA

  5. 7

    Department of Biomedical & Chemical Engineering, University of Virginia, VA, USA

Author Information

  1. 1

    Department of Chemical Engineering, University of Florida, Gainesville, FL, USA

  2. 2

    Vascular Biology Program, Departments of Pathology & Surgery, Children's Hospital and Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 11 APR 2007
  2. Published Print: 26 OCT 2007

ISBN Information

Print ISBN: 9780471925521

Online ISBN: 9780470185834

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Keywords:

  • multifunctional biomimetic materials;
  • load-bearing extracellular matrix scaffolds;
  • multimolecular signaling complex

Summary

This chapter contains sections titled:

  • Introduction

  • Solid-State Biochemistry in Focal Adhesions

  • Focal Adhesion as a Mechanotransduction Machine

  • Mechanical Control of Molecular Binding Interactions in Focal Adhesions

  • The Focal Adhesion as a Multifunctional Biomaterial

  • Conclusions

  • References