14. Multiscale Coculture Models for Orthopedic Interface Tissue Engineering

  1. Kenneth E. Gonsalves4,
  2. Craig R. Halberstadt5,6,
  3. Cato T. Laurencin7,8 and
  4. Lakshmi S. Nair7
  1. Helen H. Lu1,2 and
  2. I-Ning E. Wang3

Published Online: 11 APR 2007

DOI: 10.1002/9780470185834.ch14

Biomedical Nanostructures

Biomedical Nanostructures

How to Cite

Lu, H. H. and Wang, I.-N. E. (2007) Multiscale Coculture Models for Orthopedic Interface Tissue Engineering, in Biomedical Nanostructures (eds K. E. Gonsalves, C. R. Halberstadt, C. T. Laurencin and L. S. Nair), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470185834.ch14

Editor Information

  1. 4

    Polymer Nanotechnology Laboratory, Department of Chemistry and Center for Optoelectronics and Optical Communication, University of North Carolina, Charlotte, NC, USA

  2. 5

    Department of Surgery, Carolinas Medical Center, USA

  3. 6

    Tengion, Inc., Winston Salem, NC, USA

  4. 7

    Department of Orthopaedic Surgery, University of Virginia, VA, USA

  5. 8

    Department of Biomedical & Chemical Engineering, University of Virginia, VA, USA

Author Information

  1. 1

    Biomaterials and Interface Tissue Engineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA

  2. 2

    College of Dental Medicine, Columbia University, New York, NY, USA

  3. 3

    Department of Chemical, Biomedical and Materials Engineering, Stevens Institute of Technology, Hoboken, NJ, USA

Publication History

  1. Published Online: 11 APR 2007
  2. Published Print: 26 OCT 2007

ISBN Information

Print ISBN: 9780471925521

Online ISBN: 9780470185834

SEARCH

Keywords:

  • soft tissue-to-bone interface;
  • ligament reconstruction surgery;
  • biomimetic coculture models

Summary

This chapter contains sections titled:

  • Introduction

  • Cellular Interactions and the Soft Tissue-to-Bone Interface

  • Types of Coculture Models

  • Coculture Models for Orthopedic Interface Tissue Engineering

  • Macro- and Microscale Coculture

  • Two-Dimensional (2D) and Three-Dimensional (3D) Cocultures

  • Mechanism of Cellular Interactions During Coculture

  • Conclusions

  • Acknowledgments

  • References