Chapter 11. The Roles of High Content Cellular Imaging in Lead Optimization

  1. Steven A. Haney Ph.D.
  1. Jonathan A. Lee1,
  2. Karen Cox1,
  3. Aidas Kriauciunas2,
  4. Shaoyou Chu1

Published Online: 27 JUN 2007

DOI: 10.1002/9780470229866.ch11

Book Title

High Content Screening: Science, Techniques and Applications

High Content Screening: Science, Techniques and Applications

Additional Information

How to Cite

Lee, J. A., Cox, K., Kriauciunas, A. and Chu, S. (2007) The Roles of High Content Cellular Imaging in Lead Optimization, in High Content Screening: Science, Techniques and Applications (ed S. A. Haney), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470229866.ch11

Editor Information

  1. Department of Biological Technologies, Wyeth Research, 35 Cambridge Park Drive, Cambridge, MA 02140, USA

Author Information

  1. 1

    Departments of Lead Generation and Lead Optimization Biology, Mail Stop 0703, Lilly Corporate Center, Indianapolis, IN 46285, USA

  2. 2

    Department of Integrative Biology, Lilly Research Laboratory, Eli Lilly and Company, Indianapolis, IN 46285, USA

Publication History

  1. Published Online: 27 JUN 2007
  2. Published Print: 4 JAN 2008

ISBN Information

Print ISBN: 9780470039991

Online ISBN: 9780470229866

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CHAPTER TOOLS

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Keywords:

  • lead optimization (LO) process;
  • LO high content cellular imaging;
  • LO and drug development critical path activities

Summary

This chapter contains sections titled:

  • Introduction

  • Statistical Validation of Assays

  • High Content Cellular Imaging is a Diverse Assay Platform

  • Use of High Content Cellular Imaging for Oncology Research at Eli Lilly

  • The Future of High Content Cellular Imaging in Lead Optimization

  • Acknowledgments

  • References

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