80. Resorbable Polymer-Ceramic Composites for Orthopedic Scaffold Applications

  1. Edgar Lara-Curzio and
  2. Michael J. Readey
  1. R. Vaidyanathan1,
  2. B. Hecht1,
  3. A. Studley1,
  4. T. Phillips1,
  5. P. D. Calvert2,
  6. B. Tellis3,
  7. A. Coleman3 and
  8. J. Szivek3

Published Online: 26 MAR 2008

DOI: 10.1002/9780470291191.ch80

28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4

28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4

How to Cite

Vaidyanathan, R., Hecht, B., Studley, A., Phillips, T., Calvert, P. D., Tellis, B., Coleman, A. and Szivek, J. (2004) Resorbable Polymer-Ceramic Composites for Orthopedic Scaffold Applications, in 28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4 (eds E. Lara-Curzio and M. J. Readey), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470291191.ch80

Author Information

  1. 1

    Advanced Ceramics Research, Inc., 3292 E. Hemisphere Loop, Tucson, AZ 85706

  2. 2

    University of Arizona Arizona Material Laboratories, Tucson AZ, 85712

  3. 3

    Biomedical Engineering Interdisciplinary Program, University of Arizona, Tucson, AZ 85712

Publication History

  1. Published Online: 26 MAR 2008
  2. Published Print: 1 JAN 2004

ISBN Information

Print ISBN: 9780470051528

Online ISBN: 9780470291191

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Keywords:

  • brushite powders;
  • self-hardening cements;
  • bovine calcium hydroxyapatite;
  • hanks balanced salt solution;
  • chemically-precipitated powders

Summary

In current state-of-the-art resorbable orthopedic implant materials, loss of strength occurs before substantial mass loss in the degradation process. Materials such as 1:1 PLA:PGA copolymers become too weak to carry any load long before significant amounts of bone have grown to replace the eroded prostheses. An alternative is a two-stage implant material that is both load bearing and osteoconductive; a property of a material to encourage bone already being formed, to lie closely to or adhere to its surface. To achieve this, an interpenetrating network of osteoconductive material and strong (but degradable) biocompatible material is needed. In comparison to conventional prosthesis or scaffold manufacturing routes, rapid prototyping (RP) techniques are an attractive means of fabricating these two-stage implants. A poly butylene terephthalate polymer blend scaffold with 150-300 μm diameter interconnected pores was built using RP and coated with a thin coating of tricalcium phosphate (TCP) or hydroxy apatite suspension in a polycaprolactone matrix. Tissue culture results showed that scaffolds with such thin coatings were more conducive to growth of the cells, perhaps due to a more open scaffold, where the cells can proliferate more easily compared to the other types. The interpenetrating combination of the two biodegradable materials was designed to allow rapid bone in-growth while providing support. This preliminary study validates our hypothesis that the RP process combined with thin coating of HA can tailor an implant to the needs of a specific patient.