86. New and Conventional Simulated Body Fluids

  1. Edgar Lara-Curzio and
  2. Michael J. Readey
  1. Hiroaki Takadama1,
  2. Masami Tanahashi Hashimoto1,
  3. Yorinobu Takigawa1,
  4. Mineo Mizuno1 and
  5. Tadashi Kokubo2

Published Online: 26 MAR 2008

DOI: 10.1002/9780470291191.ch86

28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4

28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4

How to Cite

Takadama, H., Hashimoto, M. T., Takigawa, Y., Mizuno, M. and Kokubo, T. (2008) New and Conventional Simulated Body Fluids, in 28th International Conference on Advanced Ceramics and Composites B: Ceramic Engineering and Science Proceedings, Volume 25, Issue 4 (eds E. Lara-Curzio and M. J. Readey), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470291191.ch86

Author Information

  1. 1

    Materials Research and Development Laboratory, Japan Fine Ceramics Center 2-4-1 Mutsuno, Atsuta-ku, Nagoya, 456-8587, Japan

  2. 2

    Research Institute for Science and Technology, Chubu University 1200 Matsumoto-cho, Kasugai, Japan, 487-8501, Japan

Publication History

  1. Published Online: 26 MAR 2008
  2. Published Print: 1 JAN 2004

ISBN Information

Print ISBN: 9780470051528

Online ISBN: 9780470291191

SEARCH

Keywords:

  • ceramics;
  • nanoparticles;
  • silica glasses;
  • electrophoretic deposition;
  • tetramethylammoniumhydroxide

Summary

A simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma has been used widely for in vitro assessment of the bioactivity of artificial materials. A conventional SBF (c-SBF) in general use, however, has lower HCO3 and higher Cl ion concentrations than those of human blood plasma. It is known that a performance of c-SBF does not always show good reproducibility, partially due to the preparing process of SBF. In the present study, the preparation process was modified, and a newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO3, the concentration of which is lower than the level of saturation with respect to calcite. Two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration were prepared and the ion concentrations of prepared n-SBFs were unchanged at least 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs are considered to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material.