7. Nanoceramics Intercalated with Gd-DTPA for Potential Imaging of Systems In Vivo

  1. Mineo Mizuno
  1. Seo-Young Kwak1,
  2. Waltraud M. Kriven1,
  3. Robert B Clarkson2,
  4. Benjamin J. Tucker3 and
  5. R. Linn Belford3

Published Online: 27 MAR 2008

DOI: 10.1002/9780470291269.ch7

Advances in Bioceramics and Biocomposites: Ceramic Engineering and Science Proceedings, Volume 26, Number 6

Advances in Bioceramics and Biocomposites: Ceramic Engineering and Science Proceedings, Volume 26, Number 6

How to Cite

Kwak, S.-Y., Kriven, W. M., Clarkson, R. B., Tucker, B. J. and Belford, R. L. (2005) Nanoceramics Intercalated with Gd-DTPA for Potential Imaging of Systems In Vivo, in Advances in Bioceramics and Biocomposites: Ceramic Engineering and Science Proceedings, Volume 26, Number 6 (ed M. Mizuno), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470291269.ch7

Author Information

  1. 1

    Department of Materials Science and Engineering University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

  2. 2

    Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

  3. 3

    Department of Chemistry, Illinois Electron Paramagnetic Resonance Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

Publication History

  1. Published Online: 27 MAR 2008
  2. Published Print: 1 JAN 2005

ISBN Information

Print ISBN: 9781574982367

Online ISBN: 9780470291269

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Keywords:

  • nanocuamic;
  • potential;
  • osmolality;
  • molecular;
  • micrographs

Summary

Nano-sized ceramic particles, such as layered double hydroxides (LDHs) have been developed to preserve and deliver drugs or genes in the body. In this report, we describe a new ceramic contrast reagent for magnetic resonance imaging (MRI). It has been developed by intercalation of the chelate diethylenetriamine-N, N, N′, N″, N″-pentaacetate (DTPA) complexed with Gd3+ (Gd-DTPA). Its characteristic electron paramagnetic resonance (EPR) spectrum shows a slow tumbling, space-limited environment in the LDH matrix. Gd-DTPA LDH is designed to track the route of an intercalated drug and to be applied as a new nanoceramic contrast reagent for MRI in order to detect any image tumors and their dendrites. According to XRD, SEM and TEM, the nanohybrid crystal structure and morphology possess typical, two-dimensional metal ion layering. Elemental analysis (CHN and ICP) shows a stable Gd-DTPA complex in the interlayers of LDH. This idea has the potential to extend the use of nanoceramics for gene or drug delivery.