Chapter 89. Apatite Deposition on Organic–Inorganic Hybrids Prepared from Hydroxyethylmethacrylate by Modification with Alkoxysilane and Calcium Salt in Body Environment

  1. Hau-Tay Lin and
  2. Mrityunjay Singh
  1. Toshiki Miyazaki,
  2. Chikara Ohtsuki and
  3. Masao Tanihara

Published Online: 26 MAR 2008

DOI: 10.1002/9780470294758.ch89

26th Annual Conference on Composites, Advanced Ceramics, Materials, and Structures: B: Ceramic Engineering and Science Proceedings, Volume 23, Issue 4

26th Annual Conference on Composites, Advanced Ceramics, Materials, and Structures: B: Ceramic Engineering and Science Proceedings, Volume 23, Issue 4

How to Cite

Miyazaki, T., Ohtsuki, C. and Tanihara, M. (2002) Apatite Deposition on Organic–Inorganic Hybrids Prepared from Hydroxyethylmethacrylate by Modification with Alkoxysilane and Calcium Salt in Body Environment, in 26th Annual Conference on Composites, Advanced Ceramics, Materials, and Structures: B: Ceramic Engineering and Science Proceedings, Volume 23, Issue 4 (eds H.-T. Lin and M. Singh), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470294758.ch89

Author Information

  1. Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST) 8916–5, Takayama-cho, Ikoma-shi, Nara 630–0101, Japan

Publication History

  1. Published Online: 26 MAR 2008
  2. Published Print: 1 JAN 2002

ISBN Information

Print ISBN: 9780470375792

Online ISBN: 9780470294758

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Keywords:

  • bioactive ceramics;
  • apatite deposition;
  • organic-inorganic hybrids;
  • hydroxyethylmethacrylate;
  • flexible organic polymers

Summary

Bioactive ceramics have been attractive because they spontaneously bond to living bone when implanted in bony defect. However, they are much more brittle and much less flexible than natural bone. Organic-inorganic hybrids consisting of flexible organic polymers and the essential constituents of the bioactive ceramics are useful as novel bone substitutes, owing to mechanical properties analogous to those of natural bone. In the present study, organic-inorganic hybrids were synthesized from 2–hydroxyethylmethacrylate (HEMA) by modification with Si–OH groups and Ca2+ ions, which are effective constituents on the apatite formation. Bioactivity of the synthesized hybrids are estimated by examining ability of the apatite deposition in simulated body fluid (Kokubo solution). The prepared hybrids formed apatite in Kokubo solution within 1 d, when they were modified with appropriate amount of methacryloxypropyltrimethoxysilane (MPS) and CaCl2. Addition of glycerol 10 mol% to the hybrids as a plasticizer did not appreciably decrease their apatite-forming ability. These results show a potential of obtaining novel bone substitutes with high bioactivity and high flexibility.