Chapter 8. Tinkering with Transcription Factor Proteins: The Role of Transcription Factor Adaptation in Developmental Evolution

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Günter P. Wagner1 and
  2. Anna Marie Pyle1,2

Published Online: 11 JUN 2007

DOI: 10.1002/9780470319390.ch8

Tinkering: The Microevolution of Development: Novartis Foundation Symposium 284

Tinkering: The Microevolution of Development: Novartis Foundation Symposium 284

How to Cite

Wagner, G. P. and Marie Pyle, A. (2006) Tinkering with Transcription Factor Proteins: The Role of Transcription Factor Adaptation in Developmental Evolution, in Tinkering: The Microevolution of Development: Novartis Foundation Symposium 284 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470319390.ch8

Author Information

  1. 1

    Department of Ecology and Evolutionary Biology, Yale University, 327 Osborn Memorial Laboratories, 165 Prospect Street, POB 208106, New Haven, CT 06520-8106, USA

  2. 2

    Department of Molecular Biophysics and Biochemistry, Yale University, 327 Osborn Memorial Laboratories, 165 Prospect Street, POB 208106, New Haven, CT 06520-8106, USA

Publication History

  1. Published Online: 11 JUN 2007
  2. Published Print: 8 JUN 2006

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470034293

Online ISBN: 9780470319390

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Keywords:

  • transcriptional regulation evolution;
  • transcription factor protein evolution in adaptive evolution;
  • gene expression and molecular interaction stages;
  • transcription factor adaptation;
  • transcription factor protein complexes and sequence evolution

Summary

Evolution of transcriptional regulation is often seen as being driven by the origin of transcription factor binding sites in cis-regulatory DNA. But there is strong evidence that transcriptional specificity of transcription factor proteins is determined by protein–protein interaction with other transcription factors. Here we summarize the evidence that transcription factor protein function itself is evolving and suggest that this might play an integral if not leading role in the evolution of gene regulation.