Signalling Pathways Regulating Cardiac Neural Crest Migration and Differentiation

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Frances High1 and
  2. Jonathan A. Epstein2

Published Online: 11 SEP 2007

DOI: 10.1002/9780470319413.ch12

Vascular Development: Novartis Foundation Symposium 283

Vascular Development: Novartis Foundation Symposium 283

How to Cite

High, F. and Epstein, J. A. (2007) Signalling Pathways Regulating Cardiac Neural Crest Migration and Differentiation, in Vascular Development: Novartis Foundation Symposium 283 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470319413.ch12

Author Information

  1. 1

    University of Pennsylvania, BRB II/III Room 949, 421 Curie Boulevard, Philadelphia, PA 19104, USA

  2. 2

    Department of Cell and Developmental Biology, Cardiovascular Institute, University of Pennsylvania, 954 BRB II, 421 Curie Boulevard, Philadelphia, PA 19104, USA

Publication History

  1. Published Online: 11 SEP 2007
  2. Published Print: 20 JUL 2007

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470034286

Online ISBN: 9780470319413

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Keywords:

  • molecular pathways and cardiac neural crest migration;
  • signalling pathways in neural crest differentiation;
  • MRTF-B docking protein in multiple signalling;
  • semaphorin–plexin signalling;
  • receptor–ligand interaction and intracellular signalling event

Summary

A critical contribution of neural crest to the developing cardiovascular system has been recognized for nearly 25 years. Recently, however, advanced mouse genetic techniques have revealed a series of previously unrecognized molecular pathways that regulate cardiac neural crest migration and differentiation. These involve members of the bone morphogenetic protein (BMP), T-box, myocardin, Gata and Notch families. In addition, molecules previously studied for their role in axon guidance have now been implicated in neural crest and cardiovascular patterning. In particular, members of the semaphorin family of secreted guidance molecules, along with plexin and neuropilin receptors, play critical roles during aortic arch remodelling and are implicated as candidate genes for contribution to congenital heart disease.