Vascular Lumen Formation from a Cell Biological Perspective

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Tomáš Kučera,
  2. Jan Eglinger,
  3. Boris Strilić§ and
  4. Eckhard Lammert

Published Online: 11 SEP 2007

DOI: 10.1002/9780470319413.ch5

Vascular Development: Novartis Foundation Symposium 283

Vascular Development: Novartis Foundation Symposium 283

How to Cite

Kučera, T., Eglinger, J., Strilić, B. and Lammert, E. (2007) Vascular Lumen Formation from a Cell Biological Perspective, in Vascular Development: Novartis Foundation Symposium 283 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470319413.ch5

Author Information

  1. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany

  1. These authors equally contributed to this manuscript.

  2. These authors equally contributed to this manuscript.

  3. §

    These authors equally contributed to this manuscript.

  4. This paper was presented at the symposium by Eckhard Lammert, to whom correspondence should be addressed.

Publication History

  1. Published Online: 11 SEP 2007
  2. Published Print: 20 JUL 2007

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470034286

Online ISBN: 9780470319413

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Keywords:

  • Endothelial cell;
  • tube morphogenesis;
  • vascular lumen;
  • membrane traffic;
  • vacuole;
  • basement membrane;
  • apical plasma membrane;
  • polarity;
  • MDCK;
  • fly tracheae

Summary

Endothelial cells are equipped with the intrinsic ability to form tubes and sprouts with a central lumen. However, the mechanisms that allow endothelial cells to form a lumen are largely unknown. We would like to discuss critically current models of vascular lumen formation and point to many unexplored and open questions. We briefly present what vascular researchers can learn from the formation of other cell systems with a lumen, such as cysts formed by Madin-Darby Canine Kidney (MDCK) cells as well as tracheae formed by Drosophila epithelial cells. In addition, we point to a number of questions that need to be addressed to understand better the cell biology that drives the formation of a vascular lumen.