The Genetics of Vasculogenesis

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Christopher J. Drake1,
  2. Paul A. Fleming2 and
  3. W. Scott Argraves2

Published Online: 11 SEP 2007

DOI: 10.1002/9780470319413.ch6

Vascular Development: Novartis Foundation Symposium 283

Vascular Development: Novartis Foundation Symposium 283

How to Cite

Drake, C. J., Fleming, P. A. and Argraves, W. S. (2007) The Genetics of Vasculogenesis, in Vascular Development: Novartis Foundation Symposium 283 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470319413.ch6

Author Information

  1. 1

    Cardiovascular Developmental Biology Center, Department of Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA

  2. 2

    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA

Publication History

  1. Published Online: 11 SEP 2007
  2. Published Print: 20 JUL 2007

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470034286

Online ISBN: 9780470319413

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Keywords:

  • vasculogenesis;
  • angioblast;
  • endothelial cell;
  • VEGF;
  • knockout

Summary

To identify genes important to the process of vasculogenesis, we have used a novel meta-analysis approach to evaluate retrospectively the embryonic vascular anomalies observed in over 100 mouse gene knockout studies. Through application of this method, termed Approach for Ranking of Embryonic Vascular Anomalies (AREVA), 12 genes were determined to be critical to vasculogenesis. Importantly, when the 12 genes were considered with respect to VEGF–VEGFR signalling, an integrated network centreing on the ShcA/Ras/Raf/Mek/Erk pathway became apparent. Herein, we discuss how the 12 vasculogenesis-critical genes influence specific stages in the process of vasculogenesis.