Lymphangiogenesis in Development and Disease

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Taija Mäkinen1,2,† and
  2. Kari Alitalo2

Published Online: 11 SEP 2007

DOI: 10.1002/9780470319413.ch8

Vascular Development: Novartis Foundation Symposium 283

Vascular Development: Novartis Foundation Symposium 283

How to Cite

Mäkinen, T. and Alitalo, K. (2007) Lymphangiogenesis in Development and Disease, in Vascular Development: Novartis Foundation Symposium 283 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470319413.ch8

Author Information

  1. 1

    Max Planck Institute of Neurobiology, Department of Molecular Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany

  2. 2

    Molecular/Cancer Biolog y Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, P.O.B. 63 (Haartmaninkatu 8), 00014 Helsinki, Finland

  1. Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK

Publication History

  1. Published Online: 11 SEP 2007
  2. Published Print: 20 JUL 2007

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470034286

Online ISBN: 9780470319413

SEARCH

Keywords:

  • ephrin;
  • FOXC-2;
  • lymphatic remodelling;
  • lymphedema;
  • metastasis;
  • Prox1;
  • VEGFC;
  • VEGFR3

Summary

Lymphatic vessels are important for the maintenance of normal tissue fluid balance, for immune surveillance and adsorption of digested fats. In spite of their important functions in physiological as well as in various pathological conditions, including tumour metastasis, lymphoedema and inflammation, the lymphatic vessels have not received as much attention as the blood vessels, and the mechanisms regulating their development and growth have been poorly understood. However, recent studies using mouse genetic tools and primary lymphatic endothelial cell cultures have greatly increased our understanding of how the lymphatic endothelial cells differentiate, how lymphatic vessel growth is regulated and how the remodelling of the lymphatic vasculature into a functional vessel network consisting of capillaries and collecting vessels occurs. Furthermore, these studies have also provided mechanistic insights into the processes involved in pathological lymphangiogenesis.