Chapter 11. Drug Effects in Patients with Mitochondrial Diseases

  1. James A. Dykens2,
  2. Yvonne Will3
  1. Eric A. Schon,
  2. Michio Hirano,
  3. Salvatore Dimauro

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch11

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

Schon, E. A., Hirano, M. and Dimauro, S. (2008) Drug Effects in Patients with Mitochondrial Diseases, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch11

Editor Information

  1. 2

    Pfizer, Inc., Sandwich, UK

  2. 3

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. Columbia University Medical Center, New York, New York, USA

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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Keywords:

  • mitochondrial diseases and drug toxicity;
  • human nDNA pathogenic mutations in respiratory chain dysfunction;
  • dichloroacetate (DCA) treatment in MELAS

Summary

This chapter contains sections titled:

  • Mitochondrial diseases: a brief overview

  • Drug toxicity in mitochondrial diseases: direct effects

  • Drug toxicity in mitochondrial diseases: indirect effects

  • Drug toxicity in mitochondrial diseases: hypothetical effects

  • Potential therapies

  • Conclusions

  • References

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