Chapter 15. Assessment of Mitochondrial Respiratory Complex Function in Vitro and in Vivo

  1. James A. Dykens2,
  2. Yvonne Will3
  1. Mark A. Birch-Machin

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch15

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

Birch-Machin, M. A. (2008) Assessment of Mitochondrial Respiratory Complex Function in Vitro and in Vivo, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch15

Editor Information

  1. 2

    Pfizer, Inc., Sandwich, UK

  2. 3

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. Dermatological Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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CHAPTER TOOLS

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Keywords:

  • mitochondrial respiratory complex function assessment;
  • linked assay spectrophotometric measurement;
  • mitochondrial ROSs and mitochondria-targeted probe molecules

Summary

This chapter contains sections titled:

  • Spectrophotometric measurement of the activities of individual complexes I to IV

  • Spectrophotometric measurement of the activities of linked assays

  • Limitations of the assays

  • Drug-mediated toxicity

  • References

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