Chapter 19. Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening
- James A. Dykens2,
- Yvonne Will3
Published Online: 22 JAN 2008
DOI: 10.1002/9780470372531.ch19
Copyright © 2008 John Wiley & Sons, Inc.
Book Title
Drug-Induced Mitochondrial Dysfunction
Additional Information
How to Cite
McKee, E. E. (2008) Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch19
Editor Information
- 2
Pfizer, Inc., Sandwich, UK
- 3
Pfizer, Inc., Groton, Connecticut, USA
Publication History
- Published Online: 22 JAN 2008
- Published Print: 14 SEP 2008
ISBN Information
Print ISBN: 9780470111314
Online ISBN: 9780470372531
- Summary
- Chapter
- References
Keywords:
- mitochondrial protein synthesis assessment;
- drugs and mitochondrial protein synthesis;
- mitochondrial isolation and respiratory control ratio
Summary
This chapter contains sections titled:
Introduction
Antibiotics and mitochondrial protein synthesis
Methods to assess the effects of drugs on mitochondrial protein synthesis
Use of isolated intact mitochondria to assess drug susceptibility of mitochondrial protein synthesis
Mitochondrial isolation: quality and the respiratory control ratio
Mitochondrial isolation: choice of tissue
References