Chapter 20. Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis

  1. James A. Dykens3,
  2. Yvonne Will4
  1. Michel P. de Baar†,
  2. Anthony de Ronde

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch20

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

de Baar, M. P. and de Ronde, A. (2008) Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch20

Editor Information

  1. 3

    Pfizer, Inc., Sandwich, UK

  2. 4

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. Primagen, Amsterdam, The Netherlands

  1. †

    Octo-Plus N. V., Leiden, The Netherlands

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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CHAPTER TOOLS

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Keywords:

  • antiviral drugs and mitochondrial toxicity;
  • hyperlactatemia and mitochondrial dysfunction;
  • mtDNA biomarker predicting adverse effect

Summary

This chapter contains sections titled:

  • Introduction

  • Current treatments

  • Lactic acidosis

  • Lipodystrophies

  • Mitochondrial dysfunction and antiviral therapy: the DNA polymerase γ hypothesis

  • In vitro assessment of mtDNA depletion

  • Technologies for measuring mtDNA

  • Conclusions

  • References

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