Chapter 23. Development of Animal Models of Drug-Induced Mitochondrial Toxicity

  1. James A. Dykens3,
  2. Yvonne Will4
  1. Urs A. Boelsterli1,
  2. Yie Hou Lee2

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch23

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

Boelsterli, U. A. and Lee, Y. H. (2008) Development of Animal Models of Drug-Induced Mitochondrial Toxicity, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch23

Editor Information

  1. 3

    Pfizer, Inc., Sandwich, UK

  2. 4

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. 1

    Department of Pharmaceutical Sciences, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA

  2. 2

    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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Keywords:

  • mitochondrial dysfunction animal model;
  • drug-induced mitochondrial toxicity animal model;
  • mitochondrial abnormalities and idiosyncratic drug hepatotoxicity

Summary

This chapter contains sections titled:

  • Introduction

  • Animal models of mitochondrial dysfunction

  • Development of the Sod2+/− knockout mouse model for drug testing

  • Mitochondrial abnormalities: a possible link to idiosyncratic drug hepatotoxicity

  • Implications and significance of the use of animal models of mitochondrial toxicity in drug safety assessment

  • References

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