Chapter 24. Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy

  1. James A. Dykens3,
  2. Yvonne Will4
  1. Robert W. Wiseman1,
  2. J. A. L. Jeneson2

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch24

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

Wiseman, R. W. and Jeneson, J. A. L. (2008) Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch24

Editor Information

  1. 3

    Pfizer, Inc., Sandwich, UK

  2. 4

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. 1

    Biomedical Imaging Research Center, Departments of Physiology and Radiology, Michigan State University, East Lansing, Michigan, USA

  2. 2

    Biomedical NMR Laboratory, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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CHAPTER TOOLS

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Keywords:

  • mitochondrial function and noninvasive assessment;
  • mitochondrial function using P-NMR spectroscopy;
  • free ADP concentration analysis and phenotypic creatine pool

Summary

This chapter contains sections titled:

  • Introduction

  • Spin physics and the NMR experiment

  • Probing mitochondrial function using 31P-NMR spectroscopy

  • Conclusions

  • References

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