Chapter 25. Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

  1. James A. Dykens2,
  2. Yvonne Will3
  1. Michael P. Murphy

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch25

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

Murphy, M. P. (2008) Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch25

Editor Information

  1. 2

    Pfizer, Inc., Sandwich, UK

  2. 3

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. MRC Dunn Human Nutrition Unit, Wellcome Trust, Cambridge, UK

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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CHAPTER TOOLS

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Keywords:

  • mitochondria-targeted antioxidants;
  • MitoE2 and MitoQ10 in lipid peroxidation prevention;
  • mitochondrial dysfunction and reactive oxygen species (ROS)

Summary

This chapter contains sections titled:

  • Introduction

  • ROS and drug design

  • MitoQ and MitoE

  • Potential toxicity

  • Bioavailability

  • Other approaches

  • Pharmaceutical development of MitoQ10

  • Conclusions

  • References

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