Chapter 5. Features and Mechanisms of Drug-Induced Liver Injury

  1. James A. Dykens2,
  2. Yvonne Will3
  1. Dominique Pessayre,
  2. Alain Berson,
  3. Bernard Fromenty

Published Online: 22 JAN 2008

DOI: 10.1002/9780470372531.ch5

Book Title

Drug-Induced Mitochondrial Dysfunction

Drug-Induced Mitochondrial Dysfunction

Additional Information

How to Cite

Pessayre, D., Berson, A. and Fromenty, B. (2008) Features and Mechanisms of Drug-Induced Liver Injury, in Drug-Induced Mitochondrial Dysfunction (eds J. A. Dykens and Y. Will), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470372531.ch5

Editor Information

  1. 2

    Pfizer, Inc., Sandwich, UK

  2. 3

    Pfizer, Inc., Groton, Connecticut, USA

Author Information

  1. INSERM, Centre de Recherche Biomédicale Bichat Beaujon, Équipe Mitochondries et Foie, Paris; Faculté de Médecine Xavier Bichat, Université Paris 7, Paris, France

Publication History

  1. Published Online: 22 JAN 2008
  2. Published Print: 14 SEP 2008

ISBN Information

Print ISBN: 9780470111314

Online ISBN: 9780470372531

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Keywords:

  • drug-induced liver injury (DILI);
  • reactive metabolite–mediated mitochondrial disruption;
  • drugs and mitochondrial DNA interference

Summary

This chapter contains sections titled:

  • Introduction

  • General features of DILI

  • Reactive metabolite–mediated mitochondrial disruption

  • Parent drug–mediated permeability transition

  • Primary impairment of mitochondrial β-oxidation

  • Primary impairment of both β-oxidation and respiration

  • Inhibition of ATP synthase

  • Inhibition of the adenine nucleotide translocator

  • Interference with mitochondrial DNA and/or mitochondrial transcripts

  • Mechanisms behind idiosyncrasy

  • Conclusions

  • References

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