Chapter 11. The Development of Drugs: Current Concepts and Issues

  1. Arthur B. Pardee3,4 and
  2. Gary S. Stein5
  1. Barry S. Komm1 and
  2. Christopher P. Miller2

Published Online: 26 MAR 2008

DOI: 10.1002/9780470374252.ch11

The Biology and Treatment of Cancer: Understanding Cancer

The Biology and Treatment of Cancer: Understanding Cancer

How to Cite

Komm, B. S. and Miller, C. P. (2008) The Development of Drugs: Current Concepts and Issues, in The Biology and Treatment of Cancer: Understanding Cancer (eds A. B. Pardee and G. S. Stein), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470374252.ch11

Editor Information

  1. 3

    Department of Biological Chemistry, Harvard University, Dana-Farber Cancer Institute, USA

  2. 4

    Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, USA

  3. 5

    Department of Cell Biology, UMASS Memorial Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Author Information

  1. 1

    Wyeth Research, Collegeville, Pennsylvania, USA

  2. 2

    Radius Health, Cambridge, Massachusetts, USA

Publication History

  1. Published Online: 26 MAR 2008
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9780470009581

Online ISBN: 9780470374252

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Keywords:

  • drug development and drug development complexity;
  • target specificity - major stumbling block in drug development;
  • structure–activity relationship (SAR) testing and animal testing

Summary

This chapter contains sections titled:

  • Introduction

  • The Complexity of Drug Development

  • Obstacles in the Initial Stages

  • Target Identification

  • Sar and Animal Testing

  • Clinical Evaluation

  • Summary

  • References