8. Design, Conduct, and Analysis

  1. Gerald van Belle

Published Online: 26 SEP 2008

DOI: 10.1002/9780470377963.ch8

Statistical Rules of Thumb, Second Edition

Statistical Rules of Thumb, Second Edition

How to Cite

van Belle, G. (2008) Design, Conduct, and Analysis, in Statistical Rules of Thumb, Second Edition, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470377963.ch8

Author Information

  1. University of Washington, Department of Biostatistics and Department of Environmental and Occupational Health Sciences, Seattle, WA

Publication History

  1. Published Online: 26 SEP 2008
  2. Published Print: 18 AUG 2008

ISBN Information

Print ISBN: 9780470144480

Online ISBN: 9780470377963



  • randomization;
  • blocking;
  • balanced design;
  • missing data;
  • bootstrapping


This chapter contains sections titled:

  • Randomization Puts Systematic Effects into the Error Term

  • Blocking is the Key to Reducing Variability

  • Factorial Designs Should be Used to Assess Joint Effects of Variables

  • High–Order Interactions Occur Rarely

  • Balanced Designs Allow Easy Assessment of Joint Effects

  • Analysis Follows Design

  • Assess Independence, Equal Variance, and Normality‒in That Order

  • Plan to Graph the Results of an Analysis

  • Distinguish Between Design Structure and Treatment Structure

  • Make Hierarchical Analyses the Default Analysis

  • Distinguish Between Nested and Crossed Designs–Not Always Easy

  • Plan for Missing Data

  • Address Multiple Comparisons Before Starting the Study

  • Know Properties Preserved When Transforming Units

  • Consider Bootstrapping for Complex Relationships