9. Invasion Program of Normal and Cancer Stem Cells

  1. Sharmila Bapat
  1. David Olmeda1,
  2. Gema Moreno-Bueno2,
  3. David Sarrió3,
  4. José Palacios4 and
  5. Amparo Cano2

Published Online: 11 MAR 2008

DOI: 10.1002/9780470391594.ch9

Cancer Stem Cells: Identification and Targets

Cancer Stem Cells: Identification and Targets

How to Cite

Olmeda, D., Moreno-Bueno, G., Sarrió, D., Palacios, J. and Cano, A. (2008) Invasion Program of Normal and Cancer Stem Cells, in Cancer Stem Cells: Identification and Targets (ed S. Bapat), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470391594.ch9

Editor Information

  1. National Centre for Cell Science, Ganeshkhind, Pune, India

Author Information

  1. 1

    Biotechnology Program, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

  2. 2

    Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas, Madrid, Spain

  3. 3

    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK

  4. 4

    Molecular Pathology Program, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain; Servicio de Anatomía Patológica, Hospital Virgen del Rocío, Sevilla, Spain

Publication History

  1. Published Online: 11 MAR 2008
  2. Published Print: 7 NOV 2008

ISBN Information

Print ISBN: 9780470122013

Online ISBN: 9780470391594

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Keywords:

  • epithelial to mesenchymal transition (EMT) and carcinoma invasive behavior;
  • mesenchymal–epithelial transition (MET) and epithelial cell plasticity;
  • human tumor EMT inducer expression

Summary

This chapter contains sections titled:

  • Introduction

  • Basics of Tumor Progression: Invasion and Metastasis

  • Epithelial-to-Mesenchymal Transition in Development and Its Relation to The Invasive Process

  • Regulation of EMT: From Signals to Molecular Pathways

  • EMT and Cancer Stem Cells

  • Can Stem Cell Properties Be Extensive to Invasive Tumor Cells?

  • Is There a Unique EMT Program Linked to Invasion?

  • Evidence of EMT in Human Clinical Tumors

  • Expression of Mesenchymal Markers and Cadherin Switching in Carcinomas

  • Expression of EMT Inducers in Human Tumors

  • Occurrence of EMT in a Specific Subset of Breast Carcinomas

  • Conclusions and Future Perspectives

  • References