Chapter 11. Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks

  1. Anton Yuryev PhD
  1. Sergei Maslov1 and
  2. Iaroslav Ispolatov PhD2,3

Published Online: 21 APR 2008

DOI: 10.1002/9780470399279.ch11

Pathway Analysis for Drug Discovery: Computational Infrastructure and Applications

Pathway Analysis for Drug Discovery: Computational Infrastructure and Applications

How to Cite

Maslov, S. and Ispolatov, I. (2008) Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks, in Pathway Analysis for Drug Discovery: Computational Infrastructure and Applications (ed A. Yuryev), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470399279.ch11

Editor Information

  1. Ariadne Genomics Inc., 9430 Key West Avenue, Suite 113, Rockville, MD 20850, USA

Author Information

  1. 1

    Department of Physics, Brookhaven National Laboratory, Upton, NY 11973, USA

  2. 2

    Departamento de Fisica, Universidad de Santiago de Chile, Casilla 302, Correo 2, Santiago, Chile

  3. 3

    Ariadne Genomics Inc., 9430 Key West Avenue, Suite 113, Rockville, MD 20850, USA

Publication History

  1. Published Online: 21 APR 2008
  2. Published Print: 12 SEP 2008

Book Series:

  1. Wiley Series on Technologies for the Pharmaceutical Industry

Book Series Editors:

  1. Sean Ekins

ISBN Information

Print ISBN: 9780470107058

Online ISBN: 9780470399279

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Keywords:

  • concentration perturbation propagation;
  • bound and free (unbound) equilibrium concentrations;
  • reversible protein–protein bindings in intracellular signaling and regulation

Summary

This chapter contains sections titled:

  • Introduction

  • Results

  • Central Observations

  • Discussion

  • Methods

  • References