Chapter 1. Drug Metabolism: Significance and Challenges

  1. Wen Xie2,3
  1. Chandra Prakash,
  2. Alfin D. N. Vaz

Published Online: 14 MAY 2008

DOI: 10.1002/9780470409107.ch1

Book Title

Nuclear Receptors in Drug Metabolism

Nuclear Receptors in Drug Metabolism

Additional Information

How to Cite

Prakash, C. and Vaz, A. D. N. (2008) Drug Metabolism: Significance and Challenges, in Nuclear Receptors in Drug Metabolism (ed W. Xie), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409107.ch1

Editor Information

  1. 2

    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA, USA

  2. 3

    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA

Author Information

  1. Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, CT, USA

Publication History

  1. Published Online: 14 MAY 2008
  2. Published Print: 24 OCT 2008

ISBN Information

Print ISBN: 9780470086797

Online ISBN: 9780470409107

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CHAPTER TOOLS

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Keywords:

  • drug metabolism - significance and challenges;
  • Phase I drug-metabolizing enzymes;
  • drug metabolism challenges

Summary

This chapter contains sections titled:

  • Introduction

  • Phase I Drug-Metabolizing Enzymes

  • Phase II Conjugative Enzymes

  • Drug Efflux Transporters

  • Drug Uptake Transporters

  • Challenges in Drug Metabolism

  • Summary

  • References

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