Chapter 11. Emerging Role of Retinoid-Related Orphan Receptor (ROR) and its Cross Talk with LXR (Liver X Receptor) in the Regulation of Drug-Metabolizing Enzymes

  1. Wen Xie1,2
  1. Taira Wada1,2,
  2. Wen Xie1,2

Published Online: 14 MAY 2008

DOI: 10.1002/9780470409107.ch11

Book Title

Nuclear Receptors in Drug Metabolism

Nuclear Receptors in Drug Metabolism

Additional Information

How to Cite

Wada, T. and Xie, W. (2008) Emerging Role of Retinoid-Related Orphan Receptor (ROR) and its Cross Talk with LXR (Liver X Receptor) in the Regulation of Drug-Metabolizing Enzymes, in Nuclear Receptors in Drug Metabolism (ed W. Xie), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409107.ch11

Editor Information

  1. 1

    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA, USA

  2. 2

    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA

Author Information

  1. 1

    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA, USA

  2. 2

    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA

Publication History

  1. Published Online: 14 MAY 2008
  2. Published Print: 24 OCT 2008

ISBN Information

Print ISBN: 9780470086797

Online ISBN: 9780470409107

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CHAPTER TOOLS

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Keywords:

  • ROR emerging role and LXR cross talk;
  • orphan nuclear receptor RORα;
  • RORs and drug-metabolizing enzyme regulation

Summary

This chapter contains sections titled:

  • Introduction

  • Orphan Nuclear Receptor RORα

  • A Potential Role of RORs in Xeno- and Endobiotic Gene Regulation

  • LXR and Its Regulation of Drug-Metabolizing Enzymes

  • A Functional Cross Talk Between RORα and LXR in the Regulation of Xeno- and Endobiotic Genes

  • Closing Remarks

  • References

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