Chapter 2. Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors

  1. Wen Xie2,3
  1. Tao Li,
  2. Junichiro Sonoda,
  3. Ronald M. Evans

Published Online: 14 MAY 2008

DOI: 10.1002/9780470409107.ch2

Book Title

Nuclear Receptors in Drug Metabolism

Nuclear Receptors in Drug Metabolism

Additional Information

How to Cite

Li, T., Sonoda, J. and Evans, R. M. (2008) Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors, in Nuclear Receptors in Drug Metabolism (ed W. Xie), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409107.ch2

Editor Information

  1. 2

    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA, USA

  2. 3

    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA

Author Information

  1. Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA, USA

Publication History

  1. Published Online: 14 MAY 2008
  2. Published Print: 24 OCT 2008

ISBN Information

Print ISBN: 9780470086797

Online ISBN: 9780470409107

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CHAPTER TOOLS

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Keywords:

  • orphan nuclear receptors PXR and CAR;
  • Mammalian nuclear receptors;
  • orphan nuclear receptors - xenobiotic receptors

Summary

This chapter contains sections titled:

  • Introduction

  • Nuclear Receptor and Orphan Nuclear Receptor Superfamily

  • Orphan Nuclear Receptors as Xenobiotic Receptors and Their Implications in Phase I Enzyme Regulation

  • Perspective

  • References

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