Chapter 7. Animal Models of Xenobiotic Nuclear Receptors and their Utility in Drug Development
- Wen Xie2,3
Published Online: 14 MAY 2008
DOI: 10.1002/9780470409107.ch7
Copyright © 2009 John Wiley & Sons, Inc.
Book Title
Nuclear Receptors in Drug Metabolism
Additional Information
How to Cite
Gong, H. and Xie, W. (2008) Animal Models of Xenobiotic Nuclear Receptors and their Utility in Drug Development, in Nuclear Receptors in Drug Metabolism (ed W. Xie), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409107.ch7
Editor Information
- 2
Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA, USA
- 3
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
Publication History
- Published Online: 14 MAY 2008
- Published Print: 24 OCT 2008
ISBN Information
Print ISBN: 9780470086797
Online ISBN: 9780470409107
- Summary
- Chapter
- References
Keywords:
- xenobiotic nuclear receptor animal model;
- PXR and CAR gain-of-function (transgenic) mouse models;
- xenobiotic receptor models and xenobiotic receptor-mediated gene regulation
Summary
This chapter contains sections titled:
Introduction
PXR and CAR Loss-of-Function (Knock-Out) Mouse Models
PXR and CAR Gain-of-Function (Transgenic) Mouse Models
Humanized Mouse Models
Utility of Xenobiotic Mouse Models in Pharmaceutical Development
Closing Remarks
References