5. Changing Role of FTMS in Drug Metabolism

  1. Ragu Ramanathan
  1. Petia A. Shipkova Senior Research Investigator II1,
  2. Jonathan L. Josephs Principal Scientist2 and
  3. Mark Sanders Manager3

Published Online: 14 MAY 2008

DOI: 10.1002/9780470409817.ch5

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

How to Cite

Shipkova, P. A., Josephs, J. L. and Sanders, M. (2008) Changing Role of FTMS in Drug Metabolism, in Mass Spectrometry in Drug Metabolism and Pharmacokinetics (ed R. Ramanathan), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409817.ch5

Editor Information

  1. Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Princeton, NJ, USA

Author Information

  1. 1

    Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Bioanalytical and Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Pennington, NJ, USA

  2. 2

    Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Pennington, NJ, USA

  3. 3

    Thermo Fisher Scientific, Somerset, NJ, USA

Publication History

  1. Published Online: 14 MAY 2008
  2. Published Print: 12 DEC 2008

ISBN Information

Print ISBN: 9780471751588

Online ISBN: 9780470409817

SEARCH

Keywords:

  • drug metabolism and FTMS changing role;
  • next-generation FTMS and metabolite characterization;
  • metabolic stability determination and integrated strategies

Summary

This chapter contains sections titled:

  • Introduction

  • Accurate Mass Measurements and Metabolite Characterization

  • Traditional FTMS and Metabolite Characterization

  • Next-Generation FTMS and Metabolite Characterization

  • Integrated Strategies for Metabolic Stability Determination and Metabolic Soft-Spot Characterization

  • Accurate Mass Measurements for Addressing Interferences in Complex Matrices/Formulations

  • Mass Defect Filter

  • Endogenous Metabolite Profiling (Metabonomics)

  • Summary

  • References