6. High-Resolution LC–MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection

  1. Ragu Ramanathan
  1. Haiying Zhang Senior Research Investigator II1,
  2. Donglu Zhang Principal Scientist3,
  3. Mingshe Zhu Principal Scientist3 and
  4. Kenneth L. Ray Senior Scientist2

Published Online: 14 MAY 2008

DOI: 10.1002/9780470409817.ch6

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

How to Cite

Zhang, H., Zhang, D., Zhu, M. and Ray, K. L. (2008) High-Resolution LC–MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection, in Mass Spectrometry in Drug Metabolism and Pharmacokinetics (ed R. Ramanathan), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409817.ch6

Editor Information

  1. Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Princeton, NJ, USA

Author Information

  1. 1

    Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Pennington, NJ, USA

  2. 2

    Novatia, LLC, Monmouth Junction, NJ, USA

  3. 3

    Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Princeton, NJ, USA

Publication History

  1. Published Online: 14 MAY 2008
  2. Published Print: 12 DEC 2008

ISBN Information

Print ISBN: 9780471751588

Online ISBN: 9780470409817

SEARCH

Keywords:

  • MDF approach and mass defect concept;
  • high-resolution LC–MS-based mass defect filter approach;
  • MDF applicability in different drug biological matrices

Summary

This chapter contains sections titled:

  • Introduction

  • What is Mass Defect?

  • Concept of MDF

  • Implementation of MDF

  • Applications of MDF in Metabolite Identification

  • MDF in Conjunction with Control Sample Comparison

  • Comparison of MDF with Precursor Ion Scan and Constant-Neutral-Loss Scan

  • Applicability of MDF for Drugs in Different Biological Matrices

  • Summary

  • Acknowledgments

  • References