7. Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies

  1. Ragu Ramanathan
  1. Wing W. Lam Principal Scientist1,
  2. Cho-Ming Loi Associate Research Fellow2,
  3. Angus Nedderman Director3 and
  4. Don Walker Research Fellow3

Published Online: 14 MAY 2008

DOI: 10.1002/9780470409817.ch7

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Mass Spectrometry in Drug Metabolism and Pharmacokinetics

How to Cite

Lam, W. W., Loi, C.-M., Nedderman, A. and Walker, D. (2008) Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies, in Mass Spectrometry in Drug Metabolism and Pharmacokinetics (ed R. Ramanathan), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470409817.ch7

Editor Information

  1. Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Biotransformation, Pharmaceutical Candidate Optimization, Princeton, NJ, USA

Author Information

  1. 1

    Johnson and Johnson Pharmaceutical Research and Development, Department of Drug Metabolism and Pharmacokinetics, Raritan, NJ, USA

  2. 2

    Pfizer Global Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, San Diego, CA, USA

  3. 3

    Pfizer Global Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent, UK

Publication History

  1. Published Online: 14 MAY 2008
  2. Published Print: 12 DEC 2008

ISBN Information

Print ISBN: 9780471751588

Online ISBN: 9780470409817

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Keywords:

  • high-sensitivity mass spectrometry and radioactivity applications;
  • LC–ARC system with stop-flow and non-stop-flow modes;
  • low-level metabolite characterization - future trends

Summary

This chapter contains sections titled:

  • Introduction

  • Liquid Chromatography–Accurate Radioisotope Counting–Mass Spectrometry

  • 96-Well Microtiter Plates Containing Solid Scintillant

  • Future Trends in Low-Level Metabolite Characterization in Combination with LC–ARC–MS and 96-Well Plate Approach

  • Accelerator Mass Spectrometry

  • Summary

  • Acknowledgment

  • References