Chapter 6. Protease-Directed Drug Discovery

  1. Karen E. Lackey
  1. Richard Sedrani,
  2. Ulrich Hommel,
  3. Jörg Eder

Published Online: 11 JUL 2008

DOI: 10.1002/9780470423936.ch6

Book Title

Gene Family Targeted Molecular Design

Gene Family Targeted Molecular Design

Additional Information

How to Cite

Sedrani, R., Hommel, U. and Eder, J. (2008) Protease-Directed Drug Discovery, in Gene Family Targeted Molecular Design (ed K. E. Lackey), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470423936.ch6

Editor Information

  1. GlaxoSmithKline, PO Box 13398, Five Moore Drive, Research Triangle Park, NC 27709, USA

Author Information

  1. Novartis Institute for BioMedical Research, Novartis Pharma AG, WKL-136.6.93, CH-4002 Basel, Switzerland

Publication History

  1. Published Online: 11 JUL 2008
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9780470412893

Online ISBN: 9780470423936

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Keywords:

  • protease-directed drug discovery;
  • aspartic proteases and catalytic mechanisms;
  • serine proteases as drug targets

Summary

This chapter contains sections titled:

  • Introduction

  • Aspartic Proteases

  • Metalloproteases

  • Serine Proteases

  • Cysteine Proteases

  • Perspective on Proteases as Drug Targets

  • References

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