8. Liquid Chromatography and Ambient Ionization Time-of-Flight Mass Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals

  1. Imma Ferrer Research Scientist and
  2. E. Michael Thurman Director
  1. Facundo M. Fernández Assitant Professor,
  2. Christina Y. Hampton,
  3. Leonard Nyadong,
  4. Arti Navare and
  5. Mark Kwasnik

Published Online: 11 JUL 2008

DOI: 10.1002/9780470429969.ch8

Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Volume 173

Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Volume 173

How to Cite

Fernández, F. M., Hampton, C. Y., Nyadong, L., Navare, A. and Kwasnik, M. (2009) Liquid Chromatography and Ambient Ionization Time-of-Flight Mass Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals, in Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Volume 173 (eds I. Ferrer and E. M. Thurman), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470429969.ch8

Editor Information

  1. Center for Environmental Mass Spectrometry (CEMS), Department of Civil, Environmental and Architectural Engineering, University of Colorado, Boulder, CO, USA

Author Information

  1. School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA

Publication History

  1. Published Online: 11 JUL 2008
  2. Published Print: 18 MAR 2009

ISBN Information

Print ISBN: 9780470137970

Online ISBN: 9780470429969

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Keywords:

  • liquid chromatography and ambient ionization;
  • spray or jet-based ambient ionization techniques - DESI, DeSSI;
  • accurate mass DART - TOF-MS mass spectra from tablets and capsules in representative yaa-chud bag

Summary

This chapter contains sections titled:

  • Introduction

  • Spray or Jet - Based Ambient Ionization Techniques: DESI, DeSSI

  • Electric Discharge - Based Ambient Ionization Techniques: DART, ASAP, DAPCI, DBDI, and PADI

  • Ambient Gas -, Heat -, and Laser - Assisted Desorption/Ionization Techniques: ND-EESI, ELDI, LAESI, and MALDESI

  • Case Study I: Application of Liquid Chromatography Accurate-Mass MS to the Forensic Epidemiological Characterization of Counterfeit Artesunate Antimalarial Tablets

  • Case Study II: Survey of Low Quality Combination Medicines by Ambient Ionization Accurate-Mass MS

  • Conclusions

  • Acknowledgments

  • References