25. Bringing Mesenchymal Stem Cells into the Clinic

  1. Uma Lakshmipathy,
  2. Jonathan D. Chesnut and
  3. Bhaskar Thyagarajan
  1. Robert Deans

Published Online: 17 APR 2009

DOI: 10.1002/9780470454923.ch25

Emerging Technology Platforms for Stem Cells

Emerging Technology Platforms for Stem Cells

How to Cite

Deans, R. (2009) Bringing Mesenchymal Stem Cells into the Clinic, in Emerging Technology Platforms for Stem Cells (eds U. Lakshmipathy, J. D. Chesnut and B. Thyagarajan), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470454923.ch25

Editor Information

  1. Primary and Stem Cell Systems, Invitrogen Corporation, 5781 Faraday Avenue, Carlsbad, CA 92008, USA

Author Information

  1. Athersys Inc., 3201 Carnegie Avenue Cleveland, OH 44115, USA

Publication History

  1. Published Online: 17 APR 2009
  2. Published Print: 18 MAR 2009

ISBN Information

Print ISBN: 9780470146934

Online ISBN: 9780470454923

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Keywords:

  • bringing mesenchymal stem cells into clinic;
  • MSC product and reduction of graft versus host disease (GVHD) morbidity;
  • routine MSC lot release testing of clinical product

Summary

This chapter contains sections titled:

  • Origins

  • Product Development Considerations of MSC

  • Clinical Proof of Concept

  • Mechanism of Benefit

  • Manufacturing and Lot Release Criteria

  • Cytogenetic Instability and Extensive Clinical Expansion

  • Regulatory Strategies

  • Business Models

  • Future Thinking

  • References