9. Large-Scale Production of Adult Stem Cells for Clinical Use

  1. Uma Lakshmipathy,
  2. Jonathan D. Chesnut and
  3. Bhaskar Thyagarajan
  1. Kristin L. Goltry,
  2. Brian S. Hampson,
  3. Naia A. Venturi and
  4. Ronnda L. Bartel

Published Online: 17 APR 2009

DOI: 10.1002/9780470454923.ch9

Emerging Technology Platforms for Stem Cells

Emerging Technology Platforms for Stem Cells

How to Cite

Goltry, K. L., Hampson, B. S., Venturi, N. A. and Bartel, R. L. (2009) Large-Scale Production of Adult Stem Cells for Clinical Use, in Emerging Technology Platforms for Stem Cells (eds U. Lakshmipathy, J. D. Chesnut and B. Thyagarajan), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470454923.ch9

Editor Information

  1. Primary and Stem Cell Systems, Invitrogen Corporation, 5781 Faraday Avenue, Carlsbad, CA 92008, USA

Author Information

  1. Aastrom Biosciences, Inc., 24 Frank Lloyd Wright Drive, Lobby K, Ann Arbor, MI 48105, USA

Publication History

  1. Published Online: 17 APR 2009
  2. Published Print: 18 MAR 2009

ISBN Information

Print ISBN: 9780470146934

Online ISBN: 9780470454923

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Keywords:

  • cell therapy - transplantation of cells and repair or regenerating damaged cells or tissues;
  • Biologics License Approval (BLA) and compliance with Good Manufacturing Practices (GMPs);
  • postculture processing of cell products

Summary

This chapter contains sections titled:

  • Cell Therapy

  • Manufacture of Cell Products for Therapy

  • Regulatory Requirements for Cell Products

  • Cell Culture Processes

  • Importance of Medium Exchange for Maintenance of Hematopoietic Stem Cells

  • Bioreactor Design Capable of Supporting the Biologic Process

  • Cell Manufacturing System

  • Postculture Processing of Cell Products

  • Depletion of Culture Residuals from the Cell Product

  • Summary

  • Acknowledgments

  • References