Chapter 6. Application of QbD Principles to Tangential Flow Filtration Operations

  1. Anurag S. Rathore3,
  2. Rohin Mhatre4
  1. Peter K. Watler1,
  2. John Rozembersky2

Published Online: 28 OCT 2008

DOI: 10.1002/9780470466315.ch6

Book Title

Quality by Design for Biopharmaceuticals: Principles and Case Studies

Quality by Design for Biopharmaceuticals: Principles and Case Studies

Additional Information

How to Cite

Watler, P. K. and Rozembersky, J. (2008) Application of QbD Principles to Tangential Flow Filtration Operations, in Quality by Design for Biopharmaceuticals: Principles and Case Studies (eds A. S. Rathore and R. Mhatre), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470466315.ch6

Editor Information

  1. 3

    Amgen Inc., Thousand Oaks, California, USA

  2. 4

    Biogen Idec, Cambridge, Massachusetts, USA

Author Information

  1. 1

    JM Hyde Consulting, Inc., San Francisco, California, USA

  2. 2

    Rozembersky Group, Inc, Boxborough, Massachusetts, USA

Publication History

  1. Published Online: 28 OCT 2008
  2. Published Print: 8 JUN 2009

ISBN Information

Print ISBN: 9780470282335

Online ISBN: 9780470466315

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CHAPTER TOOLS

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Keywords:

  • QbD principle application to tangential flow filtration;
  • tangential flow filtration (TFF) - primary permeation driving force;
  • TFF operating parameter design

Summary

This chapter contains sections titled:

  • Introduction

  • Applications of TFF in Biotechnology

  • Tangential Flow Filtration Operating Principles

  • TFF Design Objectives

  • Membrane Selection

  • TFF Operating Parameter Design

  • TFF Diafiltration Operating Mode Design

  • Summary

  • References

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