6. Application of QbD Principles to Tangential Flow Filtration Operations

  1. Anurag S. Rathore3 and
  2. Rohin Mhatre4
  1. Peter K. Watler1 and
  2. John Rozembersky2

Published Online: 28 OCT 2008

DOI: 10.1002/9780470466315.ch6

Quality by Design for Biopharmaceuticals: Principles and Case Studies

Quality by Design for Biopharmaceuticals: Principles and Case Studies

How to Cite

Watler, P. K. and Rozembersky, J. (2008) Application of QbD Principles to Tangential Flow Filtration Operations, in Quality by Design for Biopharmaceuticals: Principles and Case Studies (eds A. S. Rathore and R. Mhatre), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470466315.ch6

Editor Information

  1. 3

    Amgen Inc., Thousand Oaks, California, USA

  2. 4

    Biogen Idec, Cambridge, Massachusetts, USA

Author Information

  1. 1

    JM Hyde Consulting, Inc., San Francisco, California, USA

  2. 2

    Rozembersky Group, Inc, Boxborough, Massachusetts, USA

Publication History

  1. Published Online: 28 OCT 2008
  2. Published Print: 8 JUN 2009

ISBN Information

Print ISBN: 9780470282335

Online ISBN: 9780470466315

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Keywords:

  • QbD principle application to tangential flow filtration;
  • tangential flow filtration (TFF) - primary permeation driving force;
  • TFF operating parameter design

Summary

This chapter contains sections titled:

  • Introduction

  • Applications of TFF in Biotechnology

  • Tangential Flow Filtration Operating Principles

  • TFF Design Objectives

  • Membrane Selection

  • TFF Operating Parameter Design

  • TFF Diafiltration Operating Mode Design

  • Summary

  • References